Inflammatory neutrophil death in cystic fibrosis paper out

Inflammatory neutrophil death in cystic fibrosis paper out

NEW PAPER

Our latest paper, from Robert Gray, in collaboration with colleagues in Edinburgh, Ireland and the USA, is now published in Thorax, demonstrating that CFTR mutation in neutrophils leads to a delay in spontaneous apoptosis, with a resultant increase in neutrophil death by NETosis. This may contribute to lung inflammation in cystic fibrosis, which could be amenable to treatment using drugs that promote an anti-inflammatory apoptotic form of neutrophil cell death.
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R.D. Gray, G. Hardisty, K.H. Regan, M. Smith, C.T. Robb, R. Duffin, A. Mackellar, J.M. Felton, L. Paemka, B.N. McCullagh, C.D Lucas, D.A. Dorward, E.F. McKone, G. Cooke, S.C. Donnelly, P. Singh, D.A. Stoltz, C. Haslett, P.B. McCray, M.K.B. Whyte, A.G. Rossi, D.J. Davidson.
Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis. 
Thorax doi: 10.1136/thoraxjnl-2017-210134

 

CF neutrophils