Aging, lung and microbiome paper

Aging, lung and microbiome paper

NEW PAPER

Our latest paper, in collaboration with Dr Dawn Bowdish and colleagues, is now published in the Journal Cell Host and Microbe. This exciting study demonstrates in mouse models that aging-associated microbiota promote inflammation, and that reversing these age-related microbiota changes represents a potential strategy for reducing age-associated inflammation and the accompanying morbidity and lung infection. Furthermore, age-associated microbiota changes can be reversed by reducing TNF using anti-TNF therapy.

Thevaranjan, N., Puchta, A, Schulz, C., Naidoo, A., Szamosi, J. C., Verschoor, C. P., Loukov, D., Schenck, L. P., Jury, J., Foley, K. J., Schertzer, J. D., Larché, M. J., Davidson, D. J., Verdú, E. F., Surette, M. G., Bowdish D. M. E.Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction.Cell Host Microbe. 21(4):455-466  PubMed

PMID:28407483  PMCID:PMC5392495  DOI:10.1016/j.chom.2017.03.002
Hear Dr Dawn Bowdish discussing the research and its implications.