Our latest paper, by Jonny Gillan, from Robert Gray’s group, is now published in the Journal of Cystic Fibrosis – freely available to read.
This research shows that a commonly used mouse model of cystic fibrosis, in which human CFTR is expressed in the guts to correct intestinal disease, also express human CFTR in their macrophages, which may contribute to decreased inflammatory changes in this model.
Macrophages from gut-corrected CF mice express human CFTR and lack a pro-inflammatory phenotype.
Gillan, J. L., Hardisty, G. R., Davidson, D. J., Gray R. D.
J. Cyst. Fibros. S1569-1993(21)02132-9
Full paper available open access at Journal of Cystic Fibrosis