Persistent Burkholderia multivorans induces less of a host response than B. cenocepacia and localizes with macrophages in the lung in a mouse model of infection.
Chu, K. K., MacDonald, K. L., Davidson, D. J., and Speert, D. P.
Infect. Immun. (2004) 10;6142-6147 PubMed
Davidson supported by funding from: Canadian CF Foundation
Differences in infection kinetics and host response between Burkholderia multivorans and Burkholderia cenocepacia were demonstrated in a pulmonary infection model in BALB/c mice. B. multivorans persisted in the lung, while B. cenocepacia was cleared. Indirect immunofluorescence and electron microscopy of B. multivorans-infected lungs localized bacteria to macrophages. Clearance of B. cenocepacia was associated with greater interleukin-1beta and neutrophil responses than the responses induced by B. multivorans. PMID:15385520