The cationic antimicrobial peptide LL-37 modulates dendritic cell development and DC-induced T cell polarisation.
Davidson, D. J.*, Currie, A. J.*, Reid, G. S. D., Bowdish, D. M. E., MacDonald, K., Ma, R., Hancock, R. E. W. and Speert, D. P.
* denotes equal contribution J. Immunol. (2004) 172;1146-1156 PubMed
Davidson supported by funding from: Wellcome Trust/ CCFF
Dendritic cells (DC) are instrumental in orchestrating an appropriately polarized Th cell response to pathogens. DC exhibit considerable phenotypic and functional plasticity, influenced by lineage, Ag engagement, and the environment in which they develop and mature. In this study, we identify the human cationic peptide LL-37, found in abundance at sites of inflammation, as a potent modifier of DC differentiation, bridging innate and adaptive immune responses. LL-37-derived DC displayed significantly up-regulated endocytic capacity, modified phagocytic receptor expression and function, up-regulated costimulatory molecule expression, enhanced secretion of Th-1 inducing cytokines, and promoted Th1 responses in vitro. LL-37 may be an attractive therapeutic candidate for manipulating T cell. PMID 14707090.
Erratum in J Immunol. 2004 Feb 15;172(4):following 2703.