Mouse models of cystic fibrosis.
Davidson, D. J., and Rolfe, M.
Trends in Genetics (2001) 17; S29-S37 PubMed
The development of mouse models for cystic fibrosis has provided the opportunity to dissect disease pathogenesis, correlate genotype and phenotype, study disease-modifying genes and develop novel therapeutics. This review discusses the successes and the challenges encountered in characterizing and optimizing these models. PMID:11585674