Our latest paper, in collaboration with Prof. Julia Dorin and colleagues, is now published (in online “pre-journal edit” form) in the European Journal of Immunology (with Open Access funded by the MRC), demonstrating that Beta-defensin 3 amplifies the response of immune cells to bacterial DNA. These immune cells recognise the bacterial DNA as being different from their own and produce a danger signal. hBD3 can amplify the danger signal, resulting in a stronger triggering of natural alarm systems and activating other immune cells that are essential in the effective protection against infections (T and B cells).
McGlasson, S. L., Semple, F., MacPherson, H., Gray, M., Davidson, D. J., Dorin, J. R.
Human Beta-defensin 3 increases the TLR9-dependent response to bacterial DNA.
Euro. J. Immunol. (2017) 47(4):658-664 DOI: 10.1002/eji.201646799