Our latest paper, from Robert Gray, in collaboration with colleagues in Edinburgh, Ireland and the USA, is now published in Thorax, demonstrating that CFTR mutation in neutrophils leads to a delay in spontaneous apoptosis, with a resultant increase in neutrophil death by NETosis. This may contribute to lung inflammation in cystic fibrosis, which could be amenable to treatment using drugs that promote an anti-inflammatory apoptotic form of neutrophil cell death.
Watch my cartoon below for a simple summary!