Our collaboration contribution to Andrew Jackson and Andrew MacDonald’s groups’ research into the stimulatory properties of RNA:DNA hybrids is now out in EMBO J.
LL-37 can mediate responses to these hybrids that stimulate cells in a TLR9 specific manner.
Rigby, R. E., Webb, L. M., Mackenzie, K. J., Li, Y., Leitch, A., Reijns, M. A., Lundie, R. J., Revuelta, A., Davidson, D. J., Diebold, S., Modis, Y., Macdonald, A. S., Jackson, A. P. (2014)
RNA:DNA hybrids are a novel molecular pattern sensed by TLR9.
EMBO J. (2014) EPub Feb 2014.