Parasites, microbiome and RSV paper

Parasites, microbiome and RSV paper

NEW PAPER

Our latest paper, in collaboration with Prof. Jurgen Schwarze and colleagues, is now published  in the Journal of Allergy and Clinical Immunology , demonstrating  in mouse models that a strictly enteric helminth infection can have remote protective antiviral effects against Respiratory Syncytial Virus infection in the lung, through induction of a microbiota-dependent type I interferon response.

McFarlane, A. J., McSorley, H. J., Davidson, D. J., Fitch, P. M., Errington, C., Mackenzie, K. J., Gollwitzer, E. S., Johnston, C. J. C., MacDonald, A. S., Edwards, M. R., Harris, N. L., Marsland, B. J., Maizels, R. M., Schwarze, J.

Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota.
J Allergy Clin Immunol (2017) S0091-6749(17)30229-4.
PMID:28196762DOI:10.1016/j.jaci.2017.01.016