NEW PAPER
Our latest paper, in collaboration with Prof. Jurgen Schwarze and colleagues, is now published in the Journal of Allergy and Clinical Immunology , demonstrating in mouse models that a strictly enteric helminth infection can have remote protective antiviral effects against Respiratory Syncytial Virus infection in the lung, through induction of a microbiota-dependent type I interferon response.
McFarlane, A. J., McSorley, H. J., Davidson, D. J., Fitch, P. M., Errington, C., Mackenzie, K. J., Gollwitzer, E. S., Johnston, C. J. C., MacDonald, A. S., Edwards, M. R., Harris, N. L., Marsland, B. J., Maizels, R. M., Schwarze, J.
Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota.
J Allergy Clin Immunol (2017) S0091-6749(17)30229-4.
PMID:28196762DOI:10.1016/j.jaci.2017.01.016